Among novel loci, sentinel SNP rs4785384, on chromosome 16q12.1 near HEAT repeat containing 3 (HEATR3) was most significantly associated with fibroids (T allele Odds Ratio [OR] = 1.08; 95% confidence interval [CI]: 1.05, 1.10; P = 1.45 × 10-9; heterogeneity p [P-Het] = 0.38). This evidence concerns the gene HEATR3 and leiomyoma.