To further investigate the link between circulatory CTHRC1 and disease status, we performed multi-analyte BioLegend immunoassays on a randomly chosen subset of twenty RA patients for levels of the inflammatory cytokines IL-1β, IL-6, IL-8, and IFNγ, which are increased in the plasma of patients with RA (6, 7) and are considered indicators of the inflammatory state. This evidence concerns the gene IL6 and rheumatoid arthritis.