CTHRC1 and rheumatoid arthritis: When median CTHRC1 plasma levels were compared across cohorts, CTHRC1 levels were significantly elevated in RA patients compared to healthy controls (Dunn's test, Bonferroni adjusted p < 0.001, Figure 1) and OA patients (Dunn's test, Bonferroni adjusted p < 0.001, Figure 1).