The observed finding of a inverse link between the FCGR2A [131R/R] susceptibility genotype and presence of the FCGR3A-V allele encoding the CD16 receptor variant with higher affinity for the IgG Fc fragment in LTRs, may in part explain a lack of association of the FcCR3A-VV genotype with DSA- mediated chronic lung allograft dysfunction. The gene discussed is FCGR2A; the disease is chronic lung allograft dysfunction.