FCGR2A and pneumococcal infection: This FCGR2A [131H/H] SNP has also been identified as a susceptibility marker associated with the severity of community-acquired pneumonia (37).Genetic variation in the FCGR2A gene has also been shown to be associated with an increased prevalence of invasive pneumococcal diseases and respiratory infections after LTx (38, 39), regardless of the site of pneumococcal infection (40).