Chordin-like 1 (CHRDL1) is a secreted glycoprotein, which is structurally related to certain BMP antagonists and plays important roles in several systems, including angiogenesis (13), neural stem cell fate determination and neurogenesis (14), kidney protection from acute and chronic injuries (15), and suppression of tumor growth and metastasis(16, 17). This evidence concerns the gene CHRDL1 and neoplasm.