S100A8 and Hyperglycemia: Moreover, given the presence of S100A8/A9-driven myelopoiesis in the setting of chronic hyperglycemia, it would also be interesting to determine whether fluctuations in glycemia, in particular transient hyperglycemia, could promote S100A8/A9 signaling to induce myelopoiesis and whether this could have downstream effects on atherogenesis.