BACE1 and early-onset autosomal dominant Alzheimer disease: While only 1.5% of the wholegenome is corresponding to protein-coding genes 1, various LongNoncoding RNAs (lncRNAs) such as BACE1-AS are closely relatedto the Alzheimer's disease (AD) 4-6, modulating Aβ formation orimpacting apoptosis 7-9.