PGP and neoplasm: Indeed, targeted delivery to mesenchymal stem cells via hybrid nanoparticles consisting of exosomes with liposomes enclosing large plasmids (a CRISPR-Cas 9 system) has recently been demonstrated60, thus the therapeutical avenue to exploit the preferential uptake by sensitive tumor cells of hybrid nanoparticles containing P-gp, acting as Trojan horses, seems to be within reach, although further experiments are required to finally confirm this hypothesis.