In TLR/RLR deficient (MyTrMa KO) mice the additional deletion of STING or cGAS (MyTrMaSt KO or MyTrMaGa KO) dramatically enhanced the susceptibility to lethal MCMV infection (from 60% to 100% lethality) and mice of both genotypes succumbed to the infection with similar kinetics as observed in IFNAR KO mice. The gene discussed is IFNAR1; the disease is infection.