CGAS and infection: While upon infection with DNA-encoded alpha-herpesvirus and gamma-herpesvirus, such as herpes simplex virus 1 (HSV-1)22, varicella zoster virus23, and murine gammaherpesvirus 6824, cGAS/STING signaling was needed to limit virus replication and to promote protection, the role of STING during the pathogenesis of CMV infection is less well understood.