Interestingly, mice with a combined deficiency of TLR, RLR and cGAS (Myd88−/−Trif−/−Mavs−/−Cgas−/−, MyTrMaGa KO mice) or STING (Myd88−/−Trif−/−Mavs−/−Tmem173−/−, MyTrMaSt KO mice) signaling succumbed to the infection within 6 days (Fig. 1a–d) and therefore showed a similar sensitivity to lethal MCMV infection as detected in IFNAR KO (Ifnar−/−) mice (Fig. 1a, b). The gene discussed is DHX58; the disease is infection.