Infection experiments with Alb+IFN-β reporter mice (AlbCre+/−Ifnbflox-βluc mice), carrying a functional reporter only in Albumin+ (Alb+) hepatocytes, revealed that hepatocytes did not contribute to the IFN-β induction in the liver between 4 and 96 hpi (Fig. 4a, b). This evidence concerns the gene IFNB1 and infection.