However, GKT771 or DC101 alone or in combination did not affect the ratio of mature (CD45+/CD11b+/F4-80+) and immature (CD45+/CD11b+/F4-80−) macrophages or the frequency of total–tumor-associated macrophage (TAM) populations (CD45+/CD11b+/CD68+/F4-80+ and CD45+/CD11b+/CD68+/F4-80−) (Fig 3B and C). The gene discussed is ITGAM; the disease is neoplasm.