To give mechanistic insight into the therapeutic effect of antiCDH11 antibody treatment observed in metastatic breast cancer cells, we further demonstrated that miR-335 mediates anti-CDH11 antibody therapy response and that an enhanced miR-335/CDH11 ratio elicits marked suppression of the CSC-like and metastatic phenotypes of invasive breast cancer (Fig. 4), thus revealing a therapeutically-exploitable inverse correlation between CDH11-enhanced CSC-like and metastatic phenotype and the expression of miR-335 in invasive breast cancer. This evidence concerns the gene CDH11 and invasive breast carcinoma.