CDH11 and breast cancer: More interestingly, the antimetastasis cum anti-CSC therapeutic effects elicited by the antibody-mediated specific targeting of CDH11 via upregulated miR-335 activity observed in vitro were validated in vivo as reflected in our preclinical demonstration of how treatment with anti-CDH11 antibody or miR-335 mimic markedly suppressed breast cancer metastasis, in vivo and ex vivo (Fig. 5).