In a bid to elucidate the underlying mechanism for the observed effects of the altered expression of CDH11 in invasive breast cancer, we tested the hypothesis that CDH11-enhanced CSC-like and metastatic phenotype is inversely correlated with the expression of miR-335 in invasive breast cancer, especially as Sandoval-Bórquez A, et al. [14] recently suggested that elevated levels of CDH11 in gastric cancer were associated with low expression of miR-335. The gene discussed is CDH11; the disease is invasive breast carcinoma.