Consistent with contemporary knowledge and in the context of the present study, it is probable that CDH11-rich metastatic breast cells harbor profound alterations in their transcriptome partly by adopting cancer-specific CDH11 splicing variants, and that these variants with their encoded proteins are not passive epiphenomena of the pathogenesis of cancerous breast cells, but rather drive metastasis, and disease progression or actively contribute to specific hallmarks of cancer [9, 10]. This evidence concerns the gene CDH11 and cancer.