The expression level of RIPK3 protein was exactly decreased in the agomiR-325-3p-treated MI mice compared to the level in MI mice, and this was accompanied by the lower expression of phosphorylated MLKL, reduced myocardial infarct size, reduced apoptotic rate of cardiomyocytes, and improved cardiac function and myocardial enzyme activities. Here, RIPK3 is linked to myocardial infarction.