Keeping in mind that immunotherapy has dramatically changed the treatment paradigm of melanoma, it is interesting to note that another study demonstrated that SAHA by inducing DR5 expression on the cell surface and downregulating c-IAP-2 and Bcl-xL is able to sensitize resistant melanoma cells to human cytotoxic T-lymphocytes (CTL) [201,202]. This evidence concerns the gene BIRC3 and melanoma.