Interestingly, BETi, such as JQ1, OTX015, CPI-0610 or I-BET762, in non-small cell lung carcinoma (NSCLC), induce strong and preferential inhibition of XIAP and c-FLIP [222], suggesting that like HDACi, these inhibitors are able to coordinate selectively and differentially the expression levels of pro-apoptotic and anti-apoptotic proteins regulating TRAIL-induced cell death. This evidence concerns the gene XIAP and non-small cell lung carcinoma.