Alternatively, since HDAC inhibitors like TRAIL display apparent selective antitumoral properties, their association with TRAIL, which restores the sensitivity of resistant tumor cells to apoptosis by coordinating the downregulation of antiapoptotic genes, including c-FLIP, XIAP, and survivin or the upregulation of TRAIL agonist receptors (DR4 and DR5), could represent a promising antitumoral approach. This evidence concerns the gene CFLAR and neoplasm.