TNFSF10 and neoplasm: Remarkably, the tumor properties of histone deacetylase inhibitors, consistent with their selective effect on pro-apoptotic genes involved in the intrinsic cell death pathway, also regulate genes associated with the extrinsic pathway, largely regulated by receptors of the TNF superfamily, including FasL, TRAIL and their cognate receptors ([132,135,136,137] and Figure 8).