In our previous study, we showed that selenomethionine (Se-Met), a major form of selenium in organisms, effectively increased oxidation resistance as well as reduced the production and deposition of Aβ and tau hyperphosphorylation in the hippocampus, cortex, and also the olfactory bulb of a triple transgenic mouse model of AD (3×Tg-AD) [9,10]. Here, MAPT is linked to Alzheimer disease.