Various mechanisms have been proposed to account for the therapeutic effects of Se-Met on AD, such as Se-Met-activated autophagy to eliminate Aβ and tau, promotion of neurogenesis in the hippocampus and reduction of inflammation and oxidative stress in the brain [9,12,13], but the foremost mechanism of the effect of Se-Met on the olfactory bulb is still unclear. Here, MAPT is linked to Alzheimer disease.