MOG and experimental autoimmune encephalomyelitis: Qin et al. reported an interesting finding whereby berberine, an isoquinoline alkaloid of medicinal plants including Coptis japonic and Phellodendron amurense with anti-inflammatory activity [35], was efficacious in the amelioration of murine experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein (MOG) [21].