Since Reg3g is critical to Muc2 distribution and spatial segregation of the gut epithelium and bacteria [62,66,67], concurrent downregulation of these genes due to a HF diet may further alter the mucus layer and reduce gut barrier defenses against microbes, resulting in bacterial contact with the epithelium, increased gut inflammation, gut tissue damage, and bacterial translocation [62]. This evidence concerns the gene MUC2 and hydrops fetalis.