Targeting CDK8 may be beneficial (I) by reducing the invasiveness and growth of solid cancers; (II) by reducing glucose uptake, leading to reduced levels of energy available to cancer cells; (III) by forcing cancer cells to differentiate as a result of the loss of self-renewal ability; and IV) by activating tumor surveillance by enhancing NK cell cytotoxicity (Figure 3). This evidence concerns the gene CDK8 and cancer.