To improve the tumor-targeting delivery of USPIO, a pancreatic cancer-targeted CKAAKN peptide (a specific Wnt-2 mimetic), with specific binding to pancreatic cancer cell membrane receptors, was conjugated on the surface of the HA–VES@USPIO nanoparticles to increase tumor-selective accumulation. Here, WNT2 is linked to familial pancreatic carcinoma.