ERVW-1 and HIV-1 infection: Since HIV-1 infection into its susceptible cells is initiated by the binding of Envelope (Env) protein to the receptor/co-receptor molecules [58,59,60,61], followed by fusion between viral and cytoplasmic membranes by gp41 of Env [62,63], SERINC-mediated inhibition of the correct fusion of the viral Env with the plasma membrane by promoting inactivation of Env [43,45,53], thereby preventing virus entry into host cells, is germane in the explanation of the role of SERINC in HIV-1 entry and thus replication.