These authors uncovered that altered methylation at the ABCG1 (ATP binding cassette subfamily G member 1), PHOSPHO1 (Phosphoethanolamine/phosphocholine phosphatase), SOCS3 (Suppressor of cytokine signaling 3), SREBF1 (Sterol regulatory element binding transcription factor 1), and TXNIP (Thioredoxin interacting protein) loci was strongly associated with future development of T2D. Here, TXNIP is linked to type 2 diabetes mellitus.