MEG3 and Other metabolic disease: Subsequent investigations have described altered DNA methylation in other genes in the famine exposed-group, including INSIGF2 (INS-IGF2 Readthrough), GNASAS1 (GNAS antisense RNA 1), MEG3 (Maternally expressed 3), IL-10 (Interleukin-10), and LEP, some of which have a known role in metabolic disorders [51].