The higher expression of CD38 observed in +12 by Athanasiadou et al. [14] was confirmed by our data with a rate of 51%; also the rates of CD49d and ZAP70 were higher in +12 CLL vs. negative FISH CLL (79% and 54% vs. 27% and 36%, respectively). This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.