Recent studies using whole exome sequencing technology revealed recurrent mutations of RHOA (Table 1) in different human lymphomas of both B-cell and T-cell origin, including angio-immunoblastic T-cell lymphoma (AITL), peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) [37,38,40], adult T-cell leukemia/lymphoma (ATL) [25,29], diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma (BL) [32,67]. This evidence concerns the gene RHOA and diffuse large B-cell lymphoma.