In Tet2-/- Rhoa G17V AITL mouse models, the expression of RHOA G17V in CD4+ T cells induced TFH cell polarization and increased proliferation through upregulation of ICOS and activation of PI3K-AKT-mTOR and MAPK pathways [36]. This evidence concerns the gene ICOS and angioimmunoblastic T-cell lymphoma.