Mutations located in genes of the Gα13-dependent pathway, including sphingosine-1-phosphate receptor 2 (S1PR2) and P2Y purinoceptor 8 (P2RY8), GNA13 (which encodes Gα13), and RHO guanine nucleotide exchange factor 1 (ARHGEF1) are found in both GCB-DLBCL (30%) and Burkitt lymphoma (15%) [84]. This evidence concerns the gene ARHGEF1 and diffuse large B-cell lymphoma.