Indeed, in T-cell lymphoma mutated RHOA is always associated with the mutations in epigenetic regulators, such as TET2, DNMT3A, and IDH2 [37,40], and studies using animal models expressing the RHOA G17V, specifically in T cells, suggest that TET2 deletion is required to develop lymphoma [36,39] (see specific paragraph in this review). This evidence concerns the gene RHOA and lymphoma.