FN1 and melanoma: We also found that RGD containing the antiplatelet disintegrin trifavin inhibited B16F10 melanoma cell-induced lung colonization in an experimental model [54], and trigramin inhibited the cell-substratum adhesion of human melanoma cells, and spreading on fibronectin and fibrinogen [55], as well as that the rhodostomin inhibited the ancrod-generated fibrin-triggered prostaglandin I2 formation of human umbilical vein endothelial cells (HUVECs) through blocking αvβ3 integrin [56,57,58].