Additional studies assess five SNPs (rs965513, rs944289, rs116909374, rs2439302, and rs966423) in 1216 patients with PTC and 1416 controls, along with the expression of seven genes (PTCSC3, MBIP, NKX2-1, FOXE1, DIRC3, PTCSC2, and NRG1) located near to the genotyped SNPs in 73 paired PTC tumor and adjacent normal tissues. The gene discussed is PTCSC3; the disease is neoplasm.