Concerning P-glycoprotein (P-gp), another crucial drug efflux transporter, although it has been reported that HDACi upregulates P-gp in colorectal cancer cells through STAT3 induction and ABCB1 posttranscriptional stabilization [115], Tomono et al. demonstrated that HDACi inhibited Snail-induced activation of P-gp in lung cancer Snail-overexpressing cells [116]. This evidence concerns the gene SNAI1 and colorectal cancer.