In a study on prostate cancer cells, silencing the AGR2 protein in the PC-3 cell line resulted in the significant reduction of cellular attachment to fibronectin, collagen I, collagen IV, laminin I and fibrinogen and was associated with the sharp decrease in the expressions of α4, α5, αV, β3 and β4 integrins [93]. Here, AGR2 is linked to Familial prostate cancer.