PTGS2 and obesity due to melanocortin 4 receptor deficiency: In addition, mTORC1 signaling acts as a key regulator of the COX-2/PG pathway through the phosphorylation of CREB-regulated transcription coactivator 2 (CRTC2) in adipocytes and has been shown to mediate obesity-induced suppression of COX-2 and beige adipogenesis in WAT [9].