PTGS2 and metabolic dysfunction-associated steatohepatitis: These findings are in agreement with those of with another report using murine models of non-alcoholic steatohepatitis (NASH), induced by a HFD- or methionine- and choline-deficient (MCD) diet, by which it was shown that the increases in hepatic COX-2 expression, and the associated inflammation in the NASH model, could be attenuated by celecoxib treatment [41].