Older age (p <0.0001, Mann-Whitney U-test), shorter LTLs (p = 0.0006, Mann-Whitney U-test), hypertension (p = 0.0128, Chi-squared test), and carotid artery plaque (p = 0.0374, Chi-squared test) were significantly associated with WMH, while none of plasma viral load load before cART, current CD4 count, CD4 nadir, or length or type of cART exposure showed any association with WMH. This evidence concerns the gene CD4 and hypertensive disorder.