In this regard, we selected four maternally imprinted genes (MEST/PEG1, SNRPN/PEG4, NNAT/PEG5, and SGCE/PEG10), three paternally imprinted loci (H19-IG DMR, IGF2 DMR0, and MEG3-IG DMR) and one obesity related gene HIF3A to check the correlation of male BMI with sperm DNA methylation. The gene discussed is HIF3A; the disease is obesity due to melanocortin 4 receptor deficiency.