Elevated hsCRP is predictive of both type 2 diabetes51 and cardiovascular risk,52 and is a risk factor for steatosis.26, 53, 54, 55, 56, 57, 58 However, its association with NASH is less clearly defined: some studies show no association between hsCRP and the severity of NAFLD,55, 56 while others found that hsCRP can discriminate between steatosis and NASH, particularly more severe NASH,26, 57, 58 and is associated with underlying fibrosis.26, 57 Thus, ALT and hsCRP may reflect different aspects of the pathogenic process, and their mutual reduction may represent separate treatment effects. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.