Accumulating evidence has indicated that NCF2 plays critical roles in the development of autoimmune diseases, such as inflammatory bowel diseases, systemic lupus erythematosus,37, 38, 39 duodenitis, and Crohn's colitis.40, 41, 42 Moreover, a recent study indicated that NCF2 may play an important role in BP changes.43 MYO1F, a member of the myosin I family, is mainly expressed in bone marrow, spleen, appendix, and lymph nodes. This evidence concerns the gene MYO1F and Crohn's colitis.