In the functional enrichment analysis of four‐finding genes, we divided the 93 obstructive CAD patients into two groups due to the expression levels of NCF2, MYO1F, S1PR4, or FCN1 (high‐expression group vs low‐expression group) and applied GSEA analysis to compare the different pathways between the two groups. The gene discussed is S1PR4; the disease is coronary artery disorder.