GNAI1 and cancer: Moreover, the α7nAChR regulates the release of the catecholamine neurotransmitter dopamine and its receptors that are expressed in many cancers and can have cancer stimulating as well as inhibitory effects pending on the expression levels of receptors of the D1-like family which increase cAMP signaling via the G-protein Gsq or receptors of the D2-like family that are coupled to the inhibitory G-protein Gi and inhibit cAMP formation 28–29.