It is like that this analysis will be the key to a better understanding of the role of adiponectin in BD because in both anorexia nervosa (40) and patients with type 1 and type 2 diabetes (41) a decreased HMW/total adiponectin and an increased LMW/total adiponectin ratio is associated with increased depressive/psychiatric symptoms. This evidence concerns the gene ADIPOQ and anorexia nervosa.