Compared to the CIA group, the relative abundance of metabolism for other amino acids (P <0.01) was significantly decreased in the CIA+HTGP group, and the relative abundance of neurodegenerative diseases was significantly decreased in the CIA+LTGP (P <0.01), CIA+MTGP (P <0.01), CIA+HTGP (P <0.01), and CIA+TG (P <0.01) groups. The gene discussed is TGM4; the disease is neurodegenerative disease.