Given that our current experiments and earlier results (17) indicated that miR-597-5p and FOSL2 have an inverse effect on EMT markers and in vitro motility in LoVo cells, we put forth a hypothesis that human colon cancer may have suppressed levels of miR-597-5p leading to FOSL2 upregulation. The gene discussed is FOSL2; the disease is malignant colon neoplasm.