Acacetin, O-methylated Apigenin, found in Robinia pseudoacacia, Turnera diffusa, and Betula pendula (87), exhibits anti-cancer effects in prostate cancer cells (88) and hepatocellular carcinoma (89) etc. Acacetin inhibits the activities and functions of both ABCB1 (90, 91) and ABCG2 (92). The gene discussed is ABCB1; the disease is cancer.