Quercetin may potentiate the effect of fludarabine and ABT-737 against CLL via Mcl-1 inhibition (220), enhance the efficacy of (1) Dox in the Dox resistant prostate cancer (PC)3 cell line (PC3/R) by down-regulating c-met (221) and Dox resistant human leukemic MDR K562/ADR cells by regulating JNK/MAPK (222), (2) TRAIL to pancreatic cancer cells through JNK-mediated cFLIP turnover (223), (3) tamoxifen in tamoxifen-resistant breast cancer cell line (MCF-7Ca/TAM-R) by up-regulating ERα and down-regulating Her-2 (224), etc. Here, MAPK8 is linked to familial pancreatic carcinoma.