Figure 2C illustrates the domain organization of full-length LRIG3 and LRIG3 ectodomain. Taken together, these results indicated the existence of sLRIG3 and that sLRIG3 could be released from glioma cells overexpressing LRIG3. As the LRIG3 antibody we used recognizes the ectodomain of LRIG3 and the molecular weight for sLRIG3 is about 110 kD, which is shorter than the full length LRIG3 in Figure 2B, sLRIG3 should be the ectodomain portion of LRIG3 protein. The gene discussed is LRIG3; the disease is central nervous system cancer.