Representative images of LRIG3 IHC staining from different grade gliomas are shown in Figure 1A, while the representative images of HE, GFAP, Iba-1, CD163, and CD31 of each grade glioma are shown in Figure S1 demonstrating that LRIG3 is mainly stained on the glial cells and low grade glioma cells. Here, LRIG3 is linked to central nervous system cancer.