GFAP and central nervous system cancer: Representative images of LRIG3 IHC staining from different grade gliomas are shown in Figure 1A, while the representative images of HE, GFAP, Iba-1, CD163, and CD31 of each grade glioma are shown in Figure S1 demonstrating that LRIG3 is mainly stained on the glial cells and low grade glioma cells.