Wang YD and co-authors described the symptomatic reactivation of hepatitis B in a 40-year-old man six months after the starting of the imatinib therapy for CML (bilirubin 3.0 mg/dL, ALT 1011 U/L, INR normal, HBV DNA 285,000 IU/mL), responding to entecavir and it was possible to continue imatinib [11]. This evidence concerns the gene GPT and chronic myelogenous leukemia, BCR-ABL1 positive.