BNP: B-type natriuretic peptide; CRT: Cardiac resynchronization therapy; ESC: European Society of Cardiology; GDMT: Guideline-directed medical therapy; HF: Heart failure; LVEF: Left ventricular ejection fraction; NT-proBNP: N-terminal pro-B-type natriuretic peptide; NYHA: New York Heart Association; PA: Pulmonary artery; PCWP: Pulmonary capillary wedge pressure; RAP: Right atrial pressure. The gene discussed is NPPB; the disease is hydrops fetalis.