BMI > 40, prior cardiac transplant, eligible for cardiac transplant, history of untreated abdominal/thoracic aneurysm >5 cm, cardiothoracic surgery within 30 days, acute myocardial infarction within 14 days, symptomatic cerebrovascular disease, or stroke, severe RV failure, active uncontrolled infection, serum creatinine >3.0 or requiring dialysis, contraindications for anticoagulation, cirrhosis of liver or AST/ALT > 3 times upper limit. The gene discussed is GPT; the disease is cerebrovascular disorder.