In addition, the enhanced migration and invasion induced by gemcitabine and VPA co-treatment were suppressed after STAT3 inhibition, which further verified that STAT3 signaling participates in mediating Bmi1 expression and the biological effect induced by VPA and gemcitabine treatment on pancreatic cancer cells induced by induced by VPA and gemcitabine treatment on pancreatic cancer cells. The gene discussed is BMI1; the disease is pancreatic neoplasm.