Integration of these two signaling pathways converges in the regulation of HH/EGFR response genes, such as SOX2, SOX9, JUN, CXCR4, and FGF19, which are cooperatively induced in response to HH and EGFR signaling activation in BCC and in tumor-initiating pancreatic cells (Eberl et al., 2012). Here, EGFR is linked to skin basal cell carcinoma.