GLI1 and medulloblastoma: Recently, Gruber and co-workers showed that inhibition of class I HDACs represses the HH-GLI signaling in Ptch1-deficient mouse medulloblastoma cells not only by decreasing the DNA binding capacity of Gli1, but also contributing to efficient Gli3 repressor formation, thus implying for the first time a direct role of acetylation in Gli processing (Gruber et al., 2018).