Activation of PI3K-AKT signaling has been found to enhance GLI1 protein stability in pancreatic and ovarian cancer (Singh et al., 2017) and in anaplastic large cell lymphoma (ALCL), where AKT1 counteracts the inhibitory effect of GSK3β on GLI1 (Singh et al., 2009). The gene discussed is AKT1; the disease is ovarian cancer.