GLI1 and diffuse large B-cell lymphoma: Further, Yoon et al. (2013) showed that the oncogene c-MYC enhances the expression of GLI1 in Burkitt lymphoma cells, by direct interaction with the E-box (CANNTG) within the 5′ regulatory region of GLI1. Recently, the beta subunit of the IKK complex (IKKβ), which is induced in response to TNFα, has been reported to increase GLI1 protein levels and transcriptional activity in diffuse large B-cell lymphoma (Agarwal et al., 2016).