TMC4 and neurodegenerative disease: Six placental eSNPs have been directly associated with either blood metabolite levels [eSNP-eGenes pairs: rs2576452-TMC4, rs2041073-HEATR4 (Shin et al., 2014), rs6743376-IL36RN (Matteini et al., 2014)], risk to neurodegenerative diseases [rs10767971-PRRG4 (Latourelle et al., 2009), rs1129187-PEX6 (Jun et al., 2016)] or cancer [rs12309274-RAD52 (Zhang et al., 2014)] (Supplementary Table S6F).