MPPE1 and cancer: Further studies will be needed in order to investigate whether these cDC1 changes are also present in the bone marrow of MDS patients, whether they are sustained by the neoplastic process or they play a causative role in it, whether they are related to the immune dysregulation occurring in MDS (67), or whether they are shared with other pathologic conditions where DCs play a crucial role, including other types of cancer, infections, chronic inflammatory diseases.