IFNAR1 and Zika virus infectious disease: Importantly, studies modeling sequential DENV followed by ZIKV infection in a variety of mouse strains, including Ifnar1−/− HLA transgenic, wildtype, and Ifnar1−/−, have demonstrated that DENV-elicited CD8+ T cells are required for protection against ZIKV infection in both non-pregnant and pregnant mice (37–39, 57).