However, mutations of SIGLEC-1, which naturally occur in small proportions of individuals, did not seem to provide protection from HIV-1 infection or attenuation of HIV-1 disease progression (39), suggesting that classical, SIGLEC-1-independent HIV-1 dissemination within in the host remains the predominant mechanisms fueling viral infection in vivo. This evidence concerns the gene SIGLEC1 and viral infectious disease.