NLRP3 and Huntington disease: In particular, we focused our attention on the two receptors NLRP3 and NLRC4. While, as expected, FLG induces NLRC4 gene modulation in HD-DC and HIV-DC (Figure 3C), NLRP3 appeared to be defective in HIV-DC, as FLG was able to induce NLRP3 expression in HD, but not in HIV-DC (Figure 3D), according to our previously published data (14).