However, the diagnostic value of Fn-Fp was limited for discriminate CD subtype from different intestinal disorders (HS: controls; IBS: Irritable Bowel Syndrome; E1: Ulcerative proctitis; E2: Distal UC; E3: Extensive UC), (all AUC <0.75, Supplementary Table 5). This evidence concerns the gene FN1 and ulcer disease.