Our previous study demonstrated that the fecal microbial ratio Fn/Bifidobacterium and Fn/Fp are useful non-invasive screen markers for early CRC, and Fn had an antagonistic effect against the probiotics Fp, Bifidobacterium lactis and Lactobacillus rhamnosus (Guo et al., 2018). This evidence concerns the gene FN1 and colorectal carcinoma.