KDR and Erythema: Dermatologic toxicities, such as rash, erythema, pruritus, acneiform rash, paronychia, telangiectasia, alopecia, changes in hair growth or pigmentation, skin discoloration, xerosis, and hand-foot skin reaction, particularly with TKIs targeting vascular endothelial growth factor receptor (VEGFR) or EGFR pathways, have been well-characterized (19–21).