In our TB murine model, there are two phases, an early phase of approximately 21 days in which the Th1-type response in the lung increases progressively and is predominant at the end of this stage, and the progressive phase that starts at day 28 post-infection in which the Th1 cytokine pattern decreases and the Th2-type response emerges in co-existence with extensive inflammatory infiltrate and progressive pneumonia, as well as an increase in the bacillary loads, which leads the animal to death (6). This evidence concerns the gene NELFCD and tuberculosis.