INS and type 2 diabetes mellitus: Studies in people with high adiposity (Dunstan et al., 2012), impaired glucose levels (Henson et al., 2016), and Type 2 diabetes (Dempsey et al., 2016a) have reported greater attenuation of postprandial insulin and glucose in response to breaking up sitting (Dempsey et al., 2016a) compared with studies in “healthy” samples (Bailey and Locke, 2015; Bailey et al., 2016; Maylor et al., 2018).