TPMT and acute lymphoblastic leukemia: Table 4A and 4B exhibits diagnostic accuracies for star allele-based molecular phenotype groups and gene-wise variant burden score groups, respectively, for 6-MP intolerance among 244 pediatric ALL patients by the last-cycle DIP of 6-MP. Of the 244 ALL patients, 189 (84.4%) exhibited no NUDT15 or TPMT variant and hence was classified into NMs for both genes (Table 4A).